The Brown vs Board of Education Case

Fifty years back when the choice was passed on in the Brown versus Board of Education case isolated educational systems went to a sudden stop. After five decades there are as yet hot discussions on the viability of such a decision. Today, while schools are not legitimately isolated, there are isolation patterns in light of the manner in which populaces accumulate in territories and the neighborhood schools are affected by such populaces. Laws have been set up to forestall isolation and youngsters have been transported across town to attempt to accomplish racial parity, yet ongoing changes to enactment have halted that too. Today, the country is isolated on the isolated school issue by and by. The principle subject of the first article is that isolation in quite a while today, doesn't take on a similar significance as it did when the Brown choice was passed on. Today, as per the creator populace unevenness has more to do with populace wants to be situated close to one another, just like the case with numerous Spanish talking and European regions of the nation(Mckenna 1995). As indicated by the creator, isolation for this situation is a constructive thing as it places individuals of a similar language in a similar zone consequently diminishing trepidation and powerlessness to work until the youngsters can create more grounded English skills(Mckenna 1995). The creator accepts that the response to bigotry isn't to constrain transporting or different strategies that will place youngsters in assorted school populaces. Rather, the creator accepts prejudice can be finished by chipping away at society in general and grasping the very contrasts that make America the country that it is today. Generally I concur with the article. I know whether I didn't communicate in English I would be reluctant to permit my youngster to be transported over the city only for racial parity inside the educational system. I would like to keep them near a comfortable territory with their natural language being spoken. I don't concur anyway with the explanation that isolated schools are not detestable. I accept there is an almost negligible difference between not pushing children and leaving them alone deserted. In the event that we don't compel the equalization of race inside the educational system we should rather be extremely mindful so as not to let the minority educational systems fall by the wayside with regards to financing and different things that make instruction conceivable. In the second article the writer accepts that isolated schools put certain understudies off guard. Refering to the issues including not getting ready kids for a normally assorted society the writer trusts it is fundamental to blend the races while understudies are youthful enough to grasp such social differences(Droesch, 1996). â€Å"With or without an integration plan set up, a significant number of our kids keep on encountering isolation and racial inclination in school. In the event that our kids keep on living in racially captivated networks and go to isolated schools, they will be at an unmistakable inconvenience in the present worldwide town. For the entirety of our area's childhood to address the difficulties of working in a multicultural world, they should have the chance to learn in a situation that advocates consideration and regard for diversity(Droesch, 1996).† The creator accepts integration plans for educational systems is a starting advance to tackling the issue of bigotry in America. I concur that isolated schools will cause a proceeded captivated mentality. I concur with the creator that we should set up our nation†s youngsters for a racially various network. I trust it is imperative to arrive at understudies when they are youthful and generally open to assorted variety. This will aid the nation†s worldwide exertion to stop prejudice. I concur more with the second article than the first if language obstructions are removed from the condition.

Innocence and Experience in Joyce, Kincaid, and Frost

It is unquestionably apparent that life and experience happens, and dispenses with or changes the nature of human guiltlessness. Obviously, this is impeccably ordinary. In any case, every now and again those experiencing such a procedure, can frequently feel enduring, misfortune, and maybe disarray. This is certainly a piece of human development. Inside our content, the perusing of the three pieces by Joyce, Kincaid, and Frost, all serve to delineate this phenomenon.Advertising We will compose a custom paper test on Innocence and Experience in Joyce, Kincaid, and Frost explicitly for you for just $16.05 $11/page Learn More â€Å"Araby† is a transitioning story of a youthful Irish Catholic kid, living in mid twentieth century Dublin. Unmistakably, toward the beginning of the story, the youngster is a dreamer. Creator James Joyce portrays his hero whose failure brief him to startling response. â€Å"My eyes were frequently brimming with tears (I was unable to explain why) and n ow and again a flood from my heart appeared to empty itself out into my bosom.† (Joyce) As the story is described by the kid presently developed, the loss of guiltlessness through recalled experience is doubly powerful and unexpected. Thinking back, the storyteller talks about himself as experiencing childhood in one of the most noticeably terrible pieces of a then cursed city. Equivalent here likewise is the boy’s feeling that his religion is vacant, formal, with no genuine and genuine consideration for his Maker and the remainder of mankind. In any case, when the kid next goes gaga for the sister of a companion, â€Å"Mangan†, he quickly encounters a type of restoration. All things considered, he is destined to be baffled as his perspective on affection is one dependent on devotion and ridiculous sentiment. He doesn't get the young lady. He grieves along these lines, â€Å"Gazing up into the obscurity I considered myself to be an animal driven and determined b y vanity, (Joyce ) Finally, the last remnants of his guiltlessness are cleansed through his genuine encounter of visiting the Arabian bazaar and understanding that it is totally different from what he’d some time ago apparent. Dim, evil, enchanting, and profoundly marketed, Araby exemplifies for the storyteller, the genuine and experienced condition of the world. Next, in Jamaica Kincaid’s one-sentence short story entitled â€Å"Girl†, the loss of honesty through experience is conveyed to the little girl by her mom, who furnishes her with a reiteration of guidance. In spite of the fact that the mother’s discourse to her little girl appears to be propelled by adoration and she gives her kid data she accepts the young lady will require so as to get by as a ladies in the Western Caribbean world, it is regardless lost guiltlessness picked up by means of the mother’s denunciation. Despite the fact that the mother gives the young lady what she accepts to be useful data on all from tasks to life and love, she shows a solid absence of trust in the child.Advertising Looking for exposition on american writing? How about we check whether we can support you! Get your first paper with 15% OFF Learn More The parent begins with revealing to her posterity, she ought to â€Å"Wash the white garments on Monday and put them on the stone pile; wash the shading garments on Tuesday and put them on the clothesline to dry; don’t walk barehead in the hot sun.† (Kincaid ) Mother at that point continues to slight the girl’s very character by advising her, â€Å"on Sundays attempt to walk like a woman dislike the prostitute you are bowed on becoming.† (Kincaid ) The youngster seems to react negligibly, both with all due respect and to get extra data. The girl claims, â€Å"but I don’t sing benna on Sundays at all and never in Sunday school.† Therefore, toward the finish of the mother’s extensive explanati on, the youth is attempted to have abandoned her adolescence, and arranged to enter the grown-up world. At long last, noticeable twentieth century American artist Robert Frost addresses guiltlessness, experience, and decision in his refrain, â€Å"The Road Not Taken†. He guaranteed that the sonnet was initially composed when he and a dear companion happened upon two comparative ways in the forested areas, and were in a bind with respect to what direction to go. The sonnet seems to advance the desire that they could investigate the two ways and would perhaps do as such, on the off chance that they could, however that reality would most likely not grant that arrangement of occasions. However realizing how route leads on to way, I questioned in the event that I should ever returned. (Ice 149) Lastly, the last point settled on by Frost is that his decision directs his loss of guiltlessness and resulting reality. He discusses a later time where he will recall:Advertising We will c ompose a custom article test on Innocence and Experience in Joyce, Kincaid, and Frost explicitly for you for just $16.05 $11/page Learn More I will be telling this with a moan Somewhere ages and ages thus: Two streets veered in a wood, and I †I took the one less went by, And that has had a significant effect. (Ice 149) obviously, it isn’t away from sort of contrast happened, and whether, it was either positive or negative, yet simply experienced. Hence, the decision blocked another experience, a sort of misfortune. Works Cited Abcarian, Richard, Samuel Cohen and Marvin Klotz, eds. Writing: The Human Experience. Bedford Saint Martin’s tenth version This article on Innocence and Experience in Joyce, Kincaid, and Frost was composed and put together by client SallyFloyd to help you with your own investigations. You are allowed to utilize it for research and reference purposes so as to compose your own paper; in any case, you should refer to it appropriately. You can give your paper here.

Why An Outline Is Important In Writing Term Paper

Why An Outline Is Important In Writing Term PaperFor some people, the whole process of writing a term paper can be intimidating. After all, it's the first time you're taking on this new task and for some reason, your brain doesn't know how to think of how to do it the right way.Your first instinct may be to quickly move the paper over to the next area, but this is not the best approach. This can leave you with multiple papers sitting around with no one to read them. By the time they have been sitting around for weeks, the only thing that has really changed is that you're now reading another one of your colleagues' papers!The best approach is to take your time when you are working on your paper. This doesn't mean that you should let it sit, though. You may find yourself going over it several times and having to start all over again if you don't get it right the first time. This is why using an outline is so important, so that you can get started right away.Why is an outline important? Writing an outline will help you work out what you want to write about in a way that will make it easier to write it. Instead of coming up with your own list of things to write about, you can use an outline as a guideline. You can then pick out the key points and figure out how to fit them into your paper.A paper outline can also be used to make sure that you don't over write your term paper. You can write too much and end up overspending your space and time, or running out of ideas. An outline gives you a starting point and a way to wrap up everything.You'll find that once you learn to use an outline, writing your term paper becomes much easier. If you go back and look at itover the course of several months, you can see that you have been able to avoid repeating yourself. You can also see exactly where each chapter starts and ends. When you are stuck, you can refer back to your outline and see where you were in terms of the chapter and how many pages you were up to.Finally, an out line will help you think about each paragraph that you are going to write. This is because it will help you decide which information you need to put in each paragraph. Instead of just typing in what you think you need to say, you will be able to think about the best ways to structure your paragraphs. By planning ahead of time, you'll be able to cut down on the number of times you need to use your imagination to make something up.The biggest problem with writing papers is that it can sometimes seem like you have to know the material inside out before you can truly get started. The best way to solve this problem is to use an outline. This is your best tool for accomplishing this task and you should make it a point to use it for all of your term paper writing projects.

Treatment of Solid Tumors including Metastatic Breast Cancer - Free Essay Example

Sample details Pages: 9 Words: 2828 Downloads: 5 Date added: 2019/02/06 Category Medicine Essay Level High school Topics: Breast Cancer Essay Did you like this example? Citizen Petition Reconsider Issuance of RMAT Designation for Therapeutic Armed Activated T Lymphocytes Treatment of Solid Tumors including Metastatic Breast Cancer The undersigned submits this petition under to request the Commissioner of Food and Drugs to reconsider issuing a Regenerative Medicine Advanced Therapy (RMAT) designation to autologous T-lymphocyte therapies for patients with malignant advanced stage solid tumors, specifically stage IV metastatic breast cancer, on the basis that it can meet an unmet medical need as substantiated by new clinical trial evidence resulting from trial involving OKT3 x Herceptin Armed Activated T Cells, Low Dose IL-2, and GM-CSF, as relevant to section 506(g) of the Federal Food, Drug, and Cosmetic Act (FDC Act), as added by section 3033 of the 21st Century Cures Act (Cures Act). A. Action Requested The Expedited Programs for Regenerative Medicine Therapies for Serious Conditions Draft Guidance for Industry states that in order for an investigational drug to receive a Regenerative Medicine Advanced Therapy (RMAT) designation it must fulfill the following criteria1:. Don’t waste time! Our writers will create an original "Treatment of Solid Tumors including Metastatic Breast Cancer" essay for you Create order It meets the definition of regenerative medicine therapy (see section I of [draft guidance] document) It is intended to treat, modify, reverse or cure a serious condition; and Preliminary clinical evidence indicates that the regenerative medicine therapy has the potential to address unmet medical needs for such condition The Expedited Programs for Regenerative Medicine Therapies for Serious Conditions Draft Guidance for Industry states that the definition of regenerative medicine therapy is1: †¢ Cell therapies, therapeutic tissue engineering products, human cell, and tissue products, and combination products using any such therapies or product And Gene therapies, including genetically modified cells, that lead to a durable modification of cells or tissues may meet the definition of a regenerative medicine therapy. In said draft guidance, unmet medical need is defined as: †¢ An unmet medical need is a condition whose treatment or diagnosis is not addressed adequately by available therapy. An unmet medical need includes an immediate need for a defined population (i.e., to treat a serious condition with no or limited treatment) or a longer-term need for society (e.g., to address the development of resistance to antibacterial drugs). We, the undersigned, petition the Commissioner of Food and Drugs to reconsider issuing an RMAT designation to autologous T-Lymphocyte therapies for solid tumors, and we offer new clinical trial data from the trial named Treatment of Stage IV Breast Cancer With OKT3 x Herceptin Armed Activated T Cells, Low Dose IL-2, And GM-CSF (NCT00027807) as clinical evidence that indicates the potential to meet an unmet medical need thereby fulfilling the requirement â€Å"that the regenerative medicine therapy has the potential to address unmet medical needs for such condition† listed in The Expedited Programs for Regenerative Medicine Therapies for Serious Conditions Draft Guidance for Industry.1 B. Statement of Grounds Cancer is the second leading cause of death in the United States, with breast cancer following lung cancer as cancers with the highest mortality rates. While there have been a number of cancer therapies found to either treat or cure early-stage cancers, late-stage solid t umors tend to elude these therapies, and as a result, there are very few therapies that can attempt to treat them. Breast cancer is a disease that affects 1 out of 8 women, with 10% of all cases eventually metastasizing 5 years after the patient has received therapy for it.2,3 Many patients receive a form of therapy for breast cancer that may involve surgery with adjuvant chemotherapy, or even in the case of high-risk breast cancer high-dose chemotherapy with a stem cell transplant. Unfortunately, relapse rates after these therapies remain high, and often times the cancer has metastasized at that point. 55-87% of women who have primary breast cancer with 10 or more axillary lymph nodes relapse within 5 years of when they were diagnosed. 4 Stage IV metastatic breast cancer represents an unmet medical need, as it is not being met by current treatments or therapies. Additionally, there is research that indicates that combination therapies would work in a more effective manner against metastatic breast cancer than a single therapy.4 Some of the therapies that are currently being considered in clinical trials involve chimeric T cells, others are looking at armed activated T cells (aATC), and others are considering antibodies.3,4 The trial in question that we are using as the basis for our petition analyzes the combination immunotherapy consisting of HER2Bi armed activated T cell infusions, IL-2, and GM-CSF.3,4 The HER2Bi or BsAb consists of two monoclonal antibodies that were heteroconjugated and used to arm the T cells. These two monoclonal antibodies were Trastuzumab (Herceptin, Genentech) and an anti-CD3 (OKT3, Centocor, Ortho-Biotech) that were prepared under Current Good Manufacturing Practice (cGMP) regulations as enforced by the Food and Drugs Administration.5 Trastuzumab or the brand name Herceptin has been approved for use in the treatment of breast cancers that overexpress the HER2/neu receptor, which is a tyrosine kinase transmembrane epidermal growth factor receptor family member.3 The HER2/neu receptor is overexpressed in many breast, ovarian, gastric, lung, prostate and oral cancers. This overexpression of HER2/neu makes it an ideal therapeutic target. 3,4 Moreover, women with HER2- cancers have fewer therapeutic options, but the trial demonstrated a positive result in those patients as well, which further supports the claim that this therapy can fulfill an unmet need for a serious condition. The OKT3 or anti-CD3 antibody targets the CD3 T cell receptor. Together they form the HER2 Bispecific antibody (HER2Bi), which is engineered to direct cytotoxicity at tumor cells that overexpress the HER2/neu receptor. In this trial, they combined the HER2Bi with Interleukin-2 and the granulocyte macrophage colony-stimulating factor (GM-CSF). Interleukin-2 is a cytokine produced by leukocytes, which increases the growth and activity of other T lymphocytes and B-lymphocytes, as well as affecting the development of the immune system. GM-CSF is another cytokine that helps create additional white blood cells specifically granulocytes, macrophages, and cells that become platelets.3 The primary endpoints of the trial were to determine the safety and maximum tolerated dose. The highest dose that was administered consisted of 20 x 10^9 aATC, and the maximum tolerated dose level was not reached, nor were there any dose-limiting toxicities observed at this dosage level. The secondary endpoints of the study were assessments of response rates: complete response (CR), stable disease (SD), partial response (PR), and no evidence of disease (NED), time to progression (TTP), and overall survival (OS). TTP and OS were measured from the date of enrollment in the trial.3 The study consisted of 23 women with stage IV metastatic breast cancer, of both HER2+ and HER2- patients, in a traditional 3+3 dose escalation design. One patient in the study died from digoxin toxicity related congestive heart failure, and the autopsy of the patient did not show any myocardial T cell infiltrates. The remaining 22 patients were evaluated at 14.5 weeks. Results showed 59.1% (13/22) of patients had SD or better (NED, PR, or SD) and 40.9% (9/22) of patients had PD. The overall survival rate of the 22 evaluable patients was 36.2 months. Within the overall survival rate, the breakdown was an overall survival rate of 57.4 months for HER2+ and 27.4 months for HER2-. The results of t his study showed that there were no major negative side effects associated with this aATC therapy. There were no cytokine storms, which has been a problematic side effect in past T-cell therapies, but there were however what the researchers designated cytokine flurries.3 And while a number of patients had to have their aATC washed to reduce side effects, not a single patient had to have their dose lowered. The main side effects observed were grade 3 chills and grade 3 headaches. The incidence of chills was 8.6%, 20.8%, and 43.1% at dose levels 1, 2, and 3, respectively. The incidence of headaches was 3.1%, 8.3%, and 19.6% at dose levels, 1, 2, and 3. Two patients were hospitalized to manage other side effects that included nausea, hypotension, vomiting, and dehydration, but after the successful resolution of these side effects they resumed the trial and continued to receive the infusions of the aATCs. In this trial, the innate cytotoxicity of T cells was redirected by the formation of the aATC (can be prepared with either CD4+ or CD8+,). Normal patients and cancer patients who rec eived this combination therapy of aATC with HER2Bi combined with IL-2 and GM-CSF both exhibited specific cytotoxicity towards target cells, and the cytotoxicity increased as the dosage amount of the aATC increased. 4 The cytotoxicity persisted for more than 54 hours towards the target cells, and other cytokines including IFN-?, TNF- ?, and GM-CSF were induced when the tumor antigen was bound to the aATC.4 This capability of the aATC to induce IFN-? when it binds to a tumor antigen may be clinically beneficial, as other studies have already shown in preclinical and clinical studies that cytotoxic T cells produce IFN-? and that IFN-? is tumoricidal.6,7 Another advantage of this particular therapy is that it does not require large quantities of HER2Bi unlike other infusional therapies that do require large doses of bispecific antibodies. In fact, billions of armed activated T cells can be armed with just milligrams of the HER2Bi antibody. The aATCs proved to be cytotoxic even towards breast cancers that had a low expression level of HER2 receptors, such as the MCF-7 breast cancer cell line. 4 The SK-BR-3 cell line, which has higher levels of HER2 receptors, had even more susceptibility to cytotoxic effects from the aATC, causing greater amounts of tumor cells to be lysed.4 This indicates that even a small amount of the combination of the anti-CD3 and anti-HER2 antibodies that are used to arm activated T cells can mediate high levels of cytotoxicity that is directed at tumor cells. Even when the levels of the tumor antigen expression is low as in the case of the MCF-7 cell line, and are able to mediate cytotoxicity in vivo for many days after infusion of the aATCs.4 The fact that that the maximum tolerated dose was not reached, that there were no dose-limiting toxicities, nor was there any evidence of a life-threatening cytokine storm, and all other side effects were relatively mild and successfully resolved supports the idea that multiple infusions of aATC in combination with IL-2 and GM-CSF were both safe and technically feasible. The results of this study showed that combining antibody targeting and T cell-mediated killing could greatly augment cytotoxicity that can be directed towards cancer cells and provides a rationale to develop new nontoxic immunological approaches that can eradicate any residual tumor cells. 4 Ultimately the researchers have concluded that multiple intravenous infusions of the HER2Bi aATC are feasible, and most of them would go to the lungs and then migrate to, and settle, in the spleen, bone marrow, and liver. This is advantageous because many breast cancers metastasize to these locations, which would make the targeting of these metastases by the aATC easier. The authors of this study had intended on moving forward with a Phase II trial, and the results supported the rationale for moving forward. However, this trial ultimately did not move forward to a Phase II trial, but it did provide the rationale for further clinical trials on similar immunotherapies. A separate trial studied the HER2Bi armed activated T cells in HER2+ colorectal cancer, both in vitro and in vivo. The aATC exhibited increased cytotoxicity against HER2+ tumor cells, and showed significant suppression of colorectal carcinoma cells in comparison to unarmed ATC. Similar to the above-mentioned breast can cer trial, researchers were able to reach these results by using a very low dose of HER2Bi, which eliminated previously seen side effects of Herceptin which included cardiotoxicity that manifested as left ventricular dysfunction and heart failure in a different research project. 8 Much like the trial conducted on metastatic breast cancer, the data in this trial also showed that aATC induced IFN-? secretion levels that were higher than those induced by unarmed ATC, As such the researchers of this trial concluded that â€Å"HER2Bi?armed ATCs with anti?tumor effects may provide a promising immunotherapy for colorectal carcinoma for the future†.9 Another Phase I trial examined the HER2Bi aATC in metastatic castrate-resistant prostate cancer. They also found an increased level of IFN-? as well as no dose-limiting toxicities that were associated with this immunotherapy. 3 out of 7 patients in this trial showed a decrease in their prostate-specific antigen (PSA) and pain levels. The results of this trial provided strong rationale to continue onto a Phase II trial.10 Furthermore, there is another trial in progress that is also researching HER2Bi armed activated T cells combined with pembrolizumab, which blocks the PD-1 pathway, in patients with metastatic bre ast cancer. The trial (NCT03272334), sponsored by the University of Virginia is currently recruiting patients, but we look forward to seeing if it reaches its primary endpoints, which are evaluating the side effects and best dose for this treatment without reaching any dose-limiting toxicities. 11 While we need to keep a watchful eye on more severe side effects such as the possibility of life-threatening cytokine storms in future trials, the fact that the trial on metastatic breast cancer only had cytokine flurries is an encouraging sign. Novel immunotherapies including T-cell therapies are making headway as therapeutics for solid tumors and is a field that holds great promise because it can boost patients preexisting tumors responses, in a nontoxic manner, specifically in tumors that have no current successful therapy options.12 We would request that the Commissioner of Food and Drugs reconsider issuing an RMAT designation to autologous T-Lymphocyte therapies for solid tumors based on the preclinical trial data as covered above from the trial Treatment of Stage IV Breast Cancer With OKT3 x Herceptin Armed Activated T Cells, Low Dose IL-2, And GM-CSF (NCT00027807). We feel that this data, along with the fact that metastatic breast cancer is a serious condition that has very few therapies available to treat, and as such is an unmet medical need, fulfills all the requirements of an RMAT designation which are listed as: It meets the definition of regenerative medicine therapy (see section I of [draft guidance] document) It is intended to treat, modify, reverse or cure a serious condition; and Preliminary clinical evidence indicates that the regenerative medicine therapy has the potential to address unmet medical needs for such condition C. Environmental Impact The petitioner hereby states that the action requested in this petition will have no environmental impact and that, therefore, an environmental assessment is not required under 21 CFR 25.30. D. Economic Impact Not applicable; this section has not been requested by the Commissioner. E. Certification The undersigned certifies, that, to the best knowledge and belief of the undersigned, this petition includes all information and views on which the petition relies, and that it includes representative data and information known to the petitioner which are unfavorable to the petition. References 1. Food and Drug Administration. (2017, November). Expedited Programs for Regenerative Medicine Therapies for Serious Conditions Draft Guidance for Industry. Retrieved December 11, 2018, from https://www.fda.gov/downloads/biologicsbloodvaccines/guidancecomplianceregulatoryinformation/guidances/cellularandgenetherapy/ucm585414.pdf 2. American Cancer Society. (n.d.). How Common Is Breast Cancer? Retrieved from https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breast-cancer.html 3. Lum, L. G., Thakur, A., Al-Kadhimi, Z., Colvin, G. A., Cummings, F. J., Legare, R. D., . . . Rathore, R. (2015). Targeted T-cell Therapy in Stage IV Breast Cancer: A Phase I Clinical Trial. Clinical Cancer Research, 21(10), 2305-2314. doi:10.1158/1078-0432.ccr-14-2280 4. Sen, M., Wankowski, D. M., Garlie, N. K., Siebenlist, R. E., Epps, D. V., Lefever, A. V., Lum, L. G. (2001). Use of Anti-CD3 Ãâ€" Anti-HER2/neu Bispecific Antibody for Redirecting Cytotoxicity of Activated T Cells Toward HER2/ neu Tumors. Journal of Hematotherapy Stem Cell Research, 10(2), 247-260. doi:10.1089/15258160151134944 5. Center for Drug Evaluation and Research. (n.d.). Manufacturing Facts About the Current Good Manufacturing Practices (CGMPs). Retrieved from https://www.fda.gov/drugs/developmentapprovalprocess/manufacturing/ucm169105.htm 6. Ogawa M, W-G Yu, K Umehara, M Iwasaki, R Wijesuriya, T Tsujimura, T Kubo, H Fujiwara and T Hamaoka. (1998). Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression. Cancer Res 58: 2426–2432. 7. Quian J-H, JA Titus, SM Andrew, D Mezzanzanica, MA Garrido, JR Wunderlich and DM Segal. (1991). Human peripheral blood lymphocytes targeted with bispecific anti- bodies release cytokines that are essential for inhibiting tumor growth. J Immunol 146:3250–3256. 8. Babar, T., Blomberg, C., Hoffner, E., Yan, X. (2014). Anti-HER2 Cancer Therapy and Cardiotoxicity. Current Pharmaceutical Design,20(30), 4911-4919. doi:10 .2174/1381612820666140604145037 9. Han, H., Ma, J., Zhang, K., Li, W., Liu, C., Zhang, Y., . . . Gao, B. (2014). Bispecific anti-CD3 x anti-HER2 antibody mediates T cell cytolytic activity to HER2-positive colorectal cancer in vitro and in vivo. International Journal of Oncology,45(6), 2446-2454. doi:10.3892/ijo.2014.2663 10. Vaishampayan, U., Thakur, A., Rathore, R., Kouttab, N., Lum, L. G. (2015). Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients. Prostate Cancer,2015, 1-10. doi:10.1155/2015/285193 11. ClinicalTrials.gov. National Library of Medicine (U.S.). (n.d.). Her2-BATS and Pembrolizumab in Metastatic Breast Cancer (Breast-47)r. Retrieved from https://clinicaltrials.gov/ct2/show/NCT03272334 12. Melton, C. (2018, November 28). Novel T-Cell Therapies Make Inroads Into Solid Tumors. Retrieved December 17, 2018, from https://www.onclive.com/publications/oncology-live/2018/vol-19-no-22/novel-tcell-therapies-make-i nroads-into-solid-tumors?p=1

Islam, A Monotheistic Religion - 1290 Words

Islam, a monotheistic religion, means submitting one’s will to Allah’s will. When Allah created the Universe, He did not invite anyone to challenge His creation. Allah has a purpose for everything He creates, therefore He does not need to explain what He does to His creation. Allah has sent messengers to convey to the human kind what is legal and illegal for them. He gave His creation different abilities; however, He has given humans the ability to obey or disobey Him. Among the messengers that God has sent, one is Mohammed (PBUH). He was given the Quran, the Word of God, to disclose the commandments of Allah. Like any other prophet, Mohammed (PBUH) used his way to guide the world to the right path. The Quran is a revelation through Gabriel (PBUH) to the prophet Mohammed (PBUH). In the holy Quran, dogs are described as loyal, self-sacrificing, and devoted to their guardian. The loyalty of dogs makes them beneficial for protection, hunting, and detection of explosives a nd drugs; Nevertheless, Muslims cannot have any physical contact with them because of their impure saliva. The prophet encouraged all the beneficent uses of dogs, like herding and hunting, however, he did not want them to have any physical contact with dogs. The prophet discouraged his companions from having pet dogs, and there was a purpose. During the era of the prophet Mohammed (PBUH), the people lived in a desert where the material resources were limited. People had to survive on minimal amounts ofShow MoreRelatedIslam Is A Monotheistic Religion2152 Words   |  9 Pages Islam is a monotheistic religion that is based on the teachings of Prophet Muhammad (PBUH) as â€Å"an expression of surrender to the will of Allah (God), the creator and sustainer of the world† (qtd. in â€Å"Islam†). In order to fully understand the religion, one must understand the history, the beliefs, and the followers of Islam. Islam is known as the most misunderstood religion in the world due to events that have occurred since the development of the religion and some of the actions of people w hoRead MoreIslam : A Monotheistic Religion1505 Words   |  7 Pages Modern Challenges Paper Islam is a monotheistic religion taking into account disclosures got by the prophet Muhammad in the seventh century A.D., which were later recorded in the Quran (or Koran), Islam s consecrated content. Islam has spread quickly during the time and today the religion is, by a few estimations, the biggest on the planet. Devotees of Islam are called Muslims. The Arabic word Islam signifies accommodation, mirroring the confidence s focal precept of submitting to Allah. 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Romeo and Juliet by William Shakespeare - 538 Words

In Friar Laurence’s soliloquy duality is present in almost the whole passage. It helps show the development of the foreshadowing of both Romeo and Juliet’s fate of their death. Mostly the duality shown is light vs. dark and good vs. evil duality, but other smaller hints of other duality themes are shown as well. Through these additions to the test, Shakespeare is able to better portray the development of themes in the following scenes. This passage contains a large amount of symbolism and imagery as well, constantly referring to the herbs and plants as Friar is looking in the field. But while there are two different duality examples, they are connected by how they both represent the overall good and bad present in the novel. This duality connects to the particular theme of the inevitability of fate. While fate is not always a bad thing, Friar Laurence sets it up as seemingly bad and almost evil, â€Å"And where the worser is predominant,† (II.iii.29) He remarks e arlier in that passage as well that nothing cannot be put to both good and bad uses, so he overall is saying that the fate at the moment is seemingly evil, but that Romeo and Juliet can turn the situation around to make it look better than it does. Going back the line about how the bad usually takes control, in the way that the two lovers are handling the situation, they only see it as bad and not the good that it has the ability to be. 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The Nature of Food and Menu Hospitality Industry

Question: Describe about The Nature of Food and Menu for Hospitality Industry. Answer: In the hospitality industry, food plays a vital part. Any hotel, serving delicious, healthy, and hygienic food at an affordable price automatically gains the attention of the customer. All the hospitality destinations appoint talented and skilled chefs and souse-chefs that can create delicious food that can be served to the customer (Chakrabarti and Scholnick, 2007). The food comprises a lot of diversity. It includes the vegetarian and non-vegetarian dishes as per the choice of the customer. The customer decides his choice of food with the help of the menu provided to him by the serving restaurant or hotel. The menu is a presentation of the food that would be served to the customer. A menu comprises the name of the dish, a small detail about what the dish is and along with that the price that would be charged by the restaurant for that dish. The food, if not presented well in the menu, then the customer could go for something else. Hence, the presentation of the menu along with the d etails of the food need to very thoughtful (Fernandes et al., 2015). Every hotel or a restaurant has a pre-decided cuisine that is served to the customers. Food comprises of thousand of dishes and cuisines that can be served to the guests. The food that needs to be served is decided by putting a through the thought process. The food that is required to be served should be according to the liking of the targeted customers. Every restaurant has a type of customer that frequented it more than others. For example, a restaurant started servicing in an old Australian neighborhood will try to serve native Australian dishes to attract more customers who are living nearby. This can be the specialty of that restaurant. The food served need to be delicious, hygienic, fresh, and healthy (Hwang and Lorenzen, 2008). Food is not limited to breakfast, lunch, and dinner. It is a vast gallery to be explored. When talking about food, then it can be a small diner serving street food, a caf serving coffee, a desert bar, a multi-cuisine restaurant, or a road-side food truck, restaurant cooking the food in front of the customer and serving, and a fast-food center. They all serve different nature of food. Some serve quick bites, and some an elaborate meal, at one place a formal dress is required to have a meal, and another place welcome all type of customers, some have timings for the service, and some are open throughout the day for the guests. Food is the attraction that brings guests again and again to the restaurant. People can adjust to the accommodation, location, the seating, or the atmosphere if the food is nice and bright which satisfed the customers taste buds. Many countries are famous for the cuisine they serve like, in Hong Kong sea-food is a specialty, India is famous for its curries, Japan is a well-known place for sushi, and Australian cuisine includes Kangaroo meat. People specially visit these countries to explore the type of food that country offers. Many people take their countrys food to other countries and sell it as a cuisine of their country (Kim, 2014). In renowned hotels, it is necessary to have at least two restaurants and a coffee shop. One of these restaurants has to serve the upscale and formal food; other can be as per the liking of the hotel management. Restaurant in a hotel may serve multi-cuisine nature of food, or a single cuisine like sea-food, Indian delicacies, Japanese cuisine, or a Chinese cuisine. People wanted to explore particular kind of cuisine can go to that restaurant to enjoy that food. Five star rated hotels have a separate department of food beverages that deals in only food and related departments (Lee, Lee and Kim, 2013). This department decides the nature of food that has to be served to the guest, how it will be served and at what time. It also decides the choice of food that should be served to the customer. It also keeps the hygiene of the food in check and makes sure that food is fresh. While exploring the hospitality management a person need to learn everything about food including other parts of th e hospitality management. This is done as food is an important part of the hospitality industry and to find success in the hospitality industry one need to be well-versed with the nature of food, and the customers and their demand and choice of food (Lee and Cranage, 2007). When a guest arrives at a place to have food, then the first thing presented to him is the menu. A menu is a presentation of the food that is going to be served in the restaurant. A menu holds the various details about the food like, a small specification regarding particular dish, the price of various dish that are served in the restaurant. As it is said first, impression is the last impression. In a case of a restaurant, its menu is the first impression that reaches the customers. That makes it compulsory that the menu should be designed with great detail (Manning and Soon, 2016). It is quite true that the primary product of a restaurant is the food it is serving which includes the atmosphere, management, and social factors. The menu cannot be considered as an overall product of a restaurant, but it is an important part of it. It acts as a key factor that attracts and satisfies the customers and thus affects the performance of the restaurant firm. A menu has various parts which require proper analysis. A menu is designed as per the atmosphere of the restaurant it can be on a paper, hardboard, or a common menu placed on a wall. Some cafes display their menu outside on the entrance to attract customers (Peplow, 2013). The pricing of the food that has to be served has to be mentioned on the menu and this is known as menu pricing. The pricing of the menu has to be a well-thought process as customers prefer to check the pricing given in the menu before placing an order. The pricing should be such that it includes the over-all expenses and profit should also be incl uded in the prices. If there are any extra tax charges, then that should also be mentioned in the menu. Menu analysis is the process that helps in giving a final look at the menu. The planning, pricing, designing, operating, and the development of menu come under the menu analysis (Thompson, 2012). A menu is a multi-dimensional part of the restaurant and needs to be well detailed. If a restaurant is serving the sea-food, then the menu of that restaurant displays all the sea-food dishes that the restaurant serves to its customers. An interesting menu always attracts extra attention. For example, a hotel with a name of Lake of Woods hand over their menu on a small wooden log, another restaurant which is famous for its banana recipes has printed their menu on an artificial banana leaf. Some menus are prepared with different and stylish names of the dishes, for example, a simple chocolate Sunday is named as Death with Chocolate which makes the guest intrude about the ice-cream and would like to order if he is a chocolate buff. Using gourmet language in a menu also attract guests to explore those dishes like souse-vide chicken, a chocolate ganache, a vanilla rosemary sorbet, or a parfait. All these stylish and gourmet words attract a lot of attention from the guest, especially in a formal restaurant. A menu should be changed time to time. This brings new customers and gives a chance to old customers to explore something new from the menu (Zhang, Wang and Zhang, 2014). In hospitality industry food and menu go hand in hand as the menu is the first presentation of the food that is going to be served to the guest. This essay discusses that proper planning is required to create some delicious, fresh and hygienic food along what to serve, how to serve and when to serve. Same goes with the menu; it has to be well presented, designed, detailed, analyzed, and planned. When both food and menu is exceptional, then the customers automatically get attracted to the restaurant and want to try the food served by it that is mentioned in the menu. The importance of both food and menu is equal to each other. Both are incomplete without the other part. Hence, it is concluded that the menu has to well present as it is the first impression of the food that would be served to the customer and then the food has to be delicious to become a success amongst the customers (Zirfas, 2013). References Chakrabarti, R. and Scholnick, B. (2007). The mechanics of price adjustment: new evidence on the (un)importance of menu costs.Managerial and Decision Economics, 28(7), pp.657-668. Fernandes, A., de Oliveira, R., Rodrigues, V., Fiates, G. and da Costa Proena, R. (2015). Perceptions of university students regarding calories, food healthiness, and the importance of calorie information in menu labelling.Appetite, 91, pp.173-178. Hwang, J. and Lorenzen, C. (2008). Effective nutrition labeling of restaurant menu and pricing of healthy menu.Journal of Foodservice, 19(5), pp.270-276. Kim, M. (2014). Study on Actual State and Importance of Selection of Healthy Korean Food Menu Items Made from Environmentally-Friendly Organic Foods - Focused on Gender-.easdl, 24(4). Lee, D., Lee, J. and Kim, M. (2013). Effect of Menu Calorie Labels on Menu Sales and Consumer's Recognition at a Korean Restaurant in a Hotel.Korean J Community Nutr, 18(5), p.505. Lee, S. and Cranage, D. (2007). The Relative Importance of Menu Attributes at Point of Menu Selection Through Conjoint Analysis.Journal of Foodservice Business Research, 10(2), pp.3-18. Manning, L. and Soon, J. (2016). Food Safety, Food Fraud, and Food Defense: A Fast Evolving Literature.Journal of Food Science, 81(4), pp.R823-R834. Peplow, M. (2013). Neolithic chefs spiced their food.Nature. Stewart, H., Hyman, J. and Dong, D. (2015). Menu Labeling Fills the Gaps in Consumers Knowledge of the Calorie Content of Restaurant Foods.Agribusiness, 31(4), pp.491-506. Thompson, H. (2012). Food science deserves a place at the table.Nature. Zirfas, J. (2013). Fast Food and Fun.Paragrana, 22(1). Zhang, S., Wang, Y. and Zhang, F. (2014). Research on Designing and Organizing Menu System for Shipborne Command and Control System.AMM, 687-691, pp.48-51.